Development and clinical application of the pigment material responded by radiation for safe radiotherapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791390
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: OSHIRO Yoshiko 筑波大学, 医学医療系, 研究員 (50550159)
• Research Collaborator: MORITAKE Takashi 筑波大学, 医学医療系, 講師 (50450432)
• Project Period (FY): 2011 – 2012
• Keywords: 放射線治療 / 放射線感応性色素素材 / ゲル線量計

Research Abstract

We developed polymer gel dosimeter made from natural polymer as base matrix and methacrylate monomer that can show irradiation field and dose just after the radiotherapy. Using this, we have made proof of the concept that we can conduct radiotherapy more safely if we can confirm irradiation field and irradiated doses just after the radiotherapy. We has already applied to patent the concept and developed polymer gel. Also, we are planning to file international patent, and to put into production.

Research Products

• [Journal Article] Delayed radiotherapy for patients with localized prostate cancer: validation by propensity score matching (2013)
  • Author(s): Nakayama H, Kanemoto A, Kikuchi K, Matsuki K, Tomobe M, Tsukamoto S, Takeshima H, Oshiro Y, Sugahara S, Tokuuye K
  • Journal Title: Anticancer Res Volume: 33(4) Pages: 1629-33
  • Peer Reviewed
• [Journal Article] The use of proton-beam therapy in the treatment of non-small-cell lung cancer (2013)
  • Author(s): Oshiro Y, Sakurai H
  • Journal Title: Expert Rev Med Devices Volume: 10(2) Pages: 239-45
  • DOI: doi:10.1586/erd.12.81
  • Peer Reviewed
• [Journal Article] Proton beam therapy for unresectable hepatoblastoma in children: survival in one case (2013)
  • Author(s): Oshiro Y, Okumura T, Mizumoto M, Fukushima T, Ishikawa H, Hashimoto T, Tsuboi K, Kaneko M, Sakurai H
  • Journal Title: Acta Oncol Volume: 52(3) Pages: 600-3
  • DOI: doi:10.3109/0284186X.2012.760849
  • Peer Reviewed
• [Journal Article] Dose-volume histogram analysis for risk factors of radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma (2013)
  • Author(s): Kanemoto A, Mizumoto M, Okumura T, Takahashi H, Hashimoto T, Oshiro Y, Fukumitsu N, Moritake T, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Acta Oncol Volume: 52(3) Pages: 538-44
  • DOI: doi:10.3109/0284186X.2012.718094
  • Peer Reviewed
• [Journal Article] Proton beam therapy for inoperable recurrence of bronchial high-grade mucoepidermoid carcinoma (2012)
  • Author(s): Kanemoto A, Oshiro Y, Sugahara S, Kamagata S, Hirobe S, Toma M, Okumura T, Sakurai H
  • Journal Title: Jpn J Clin Oncol Volume: 42(6) Pages: 552-5
  • DOI: doi:10.1093/jjco/hys047
  • Peer Reviewed
• [Journal Article] Evaluation of liver function after proton beam therapy for hepatocellular carcinoma (2012)
  • Author(s): Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y, Fukumitsu N, Abei M, Kawaguchi A, Hayashi Y, Ohkawa A, Hashii H, Kanemoto A, Moritake T, Tohno E, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(3) Pages: e529-35
  • DOI: doi:10.1016/j.ijrobp.2011.05.056
  • Peer Reviewed
• [Journal Article] Verification of beam delivery using fibrosis after proton beam irradiation to the lung tumor (2012)
  • Author(s): Fukumitsu N, Oshiro Y, Hashimoto T, Okumura T, Mizumoto M, Moritake T, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Lung Cancer Volume: 77(1) Pages: 83-8
  • DOI: doi:10.1016/j.lungcan.2012.01.007
  • Peer Reviewed
• [Journal Article] Results of proton beam therapy without concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer (2012)
  • Author(s): Oshiro Y, Mizumoto M, Okumura T, Hashimoto T, Fukumitsu N, Ohkawa A, Kanemoto A, Hashii H, Ohno T, Sakae T, Tsuboi K, Sakurai H
  • Journal Title: J Thorac Oncol Volume: 7(2) Pages: 370-5
  • DOI: doi:10.1097/JTO.0b013e31823c485f
  • Peer Reviewed
• [Journal Article] Outcome of T4 (International Union Against Cancer Staging System, 7th edition) or recurrent nasal cavity and paranasal sinus carcinoma treated with proton beam (2012)
  • Author(s): Fukumitsu N, Okumura T, Mizumoto M, Oshiro Y,Hashimoto T, Kanemoto A, Hashii H, Ohkawa A, Moritake T, Tsuboi K, Tabuchi K, Wada T, Hara A, Sakurai H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 83(2) Pages: 704-11
  • DOI: doi:10.1016/j.ijrobp.2011.07.032
  • Peer Reviewed
• [Journal Article] Displacement of hepatic tumor at time to exposure in end-expiratory-triggered-pulse proton therapy (2011)
  • Author(s): Oshiro Y, Okumura T, Ishida M, Sugahara S, Mizumoto M, Hashimoto T, Yasuoka K, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Radiother Oncol Volume: 99(2) Pages: 124-30
  • DOI: doi:10.1016/j.radonc.2011.05.009
  • Peer Reviewed
• [Journal Article] Hyperfractionated concomitant boost proton beam therapy for esophageal carcinoma (2011)
  • Author(s): Mizumoto M, Sugahara S, Okumura T, Hashimoto T, Oshiro Y, Fukumitsu N, Nakahara A, Terashima H, Tsuboi K, Sakurai H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 15 Pages: 81(4)
  • DOI: doi:10.1016/j.ijrobp.2011.02.041
  • Peer Reviewed
• [Journal Article] Pediatric nasopharyngeal carcinoma treated with proton beam therapy. Two case reports (2011)
  • Author(s): Oshiro Y, Sugahara S,Fukushima T, Okumura T, Nakao T, Mizumoto M, Hashimoto T, Tsuboi K, Kaneko M, Sakurai H
  • Journal Title: Acta Oncol Volume: 50(3) Pages: 470-3
  • DOI: doi:10.3109/0284186X.2010.509106
  • Peer Reviewed
• [Journal Article] Proton beam therapy for hepatocellular carcinoma: a comparison of three treatment protocols (2011)
  • Author(s): Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y,Fukumitsu N, Abei M, Kawaguchi A, Hayashi Y, Ookawa A, Hashii H, Kanemoto A, Moritake T, Tohno E, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 81(4) Pages: 1039-45
  • DOI: doi:10.1016/j.ijrobp.2010.07.015
  • Peer Reviewed
• [Journal Article] Role of radiotherapy for local control of asymptomatic adrenal metastasis from lung cancer (2011)
  • Author(s): Oshiro Y, Takeda Y, Hirano S, Ito H, Aruga T.
  • Journal Title: Am J Clin Oncol Volume: 34(3) Pages: 249-53
  • DOI: doi:10.1097/COC.0b013e3181dbb727
  • Peer Reviewed
• [Presentation] ESTRO 31 (2012)
  • Author(s): Oshiro Y, 他10 名
  • Organizer: Preliminary clinical results of proton beam therapy for advanced neuroblastoma
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20120509-13
• [Presentation] 切除不能肝芽腫に陽子線治療を施行し (2012)
  • Author(s): 大城佳子、他9名
  • Organizer: 長期生存が得られた1例 粒子線治療研究会
  • Place of Presentation: 指宿
  • Year and Date: 2012-10-13
• [Presentation] 小児神経芽細胞腫に対する陽子線治療の初期経験 (2011)
  • Author(s): 大城 佳子、他10名
  • Organizer: 第24回放射線腫瘍学会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 20111117-19
• [Presentation] Results of proton beams radiotherapy without concurrent chemotherapy for patients with unresectable stage III non-small-cell Lung cancer (2011)
  • Author(s): Oshiro Y,他12 名
  • Organizer: ASTRO's 53^<rd>annual Meeting
  • Place of Presentation: Miami Beach Convention Center, Miami Beach, America
  • Year and Date: 20111002-06
• [Patent(Industrial Property Rights)] ポリマーゲル線量計 (2013)
  • Inventor(s): 水本佳子(旧姓:大城),盛武敬,廣木章博,田口光正,山下真一
  • Industrial Property Rights Holder: 筑波大学,原子力開発機構
  • Industrial Property Number: 110000855
  • Filing Date: 2013-03-25