2012 Fiscal Year Final Research Report
Development of a radioactive low-molecular weight probe for the specific imaging of HIF-1-active hypoxic tumors
| Project/Area Number |
23791412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Okayama University (2012)
Kyoto University (2011) |
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Principal Investigator |
UEDA Masashi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40381967)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射性医薬品 / 分子イメージング / がん / 低酸素 / HIF-1 |
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| Research Abstract |
Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumor progression and in the development of resistance to radiotherapy. To image HIF-1-active tumors, a peptide probe (^I-DKOP30) was designed and synthesized that contains an essential sequence of the oxygen-dependent degradation of HIF-1a. ^I-DKOP30 showed higher accumulation in hypoxic cells than normoxic cells. Biodistribution analysis showed ^I-DKOP30 accumulation in tumors. The tumors were clearly visualized by in vivoimaging, and intratumoral distribution of ^I-DKOP30 coincided with the HIF-1a-positive hypoxic regions. Thus, ^I-DKOP30 is a useful peptide probe for the imaging of HIF-1-active tumors.
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Research Products
(8 results)
