2013 Fiscal Year Final Research Report
T1rho MR imaging for the evaluation of the denaturelizatoin of articular cartilage caused by osteoarthritis
Project/Area Number |
23791431
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kyushu University |
Principal Investigator |
TAKAYAMA Yukihisa 九州大学, 医学(系)研究科(研究院), 助教 (60546563)
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Project Period (FY) |
2011 – 2013
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Keywords | 変形性膝関節症 / MRI / T1ρ / 関節軟骨 / 膝関節 |
Research Abstract |
T1rho mapping is one of the quantitative MR imaging techniques for the assessment of articular cartilage, because it can quantitatively evaluate the contents of extracellular matrices, such as collagen and proteoglycan (PG), in the cartilage. At the early stage of osteoarthritis (OA), PG depletion occurs prior to the decrease in collagen. It is presumed that T1rho mapping is sensitive enough to detect PG depletion at the early stage of OA. Therefore, we evaluated the clinical utility of T1rho mapping as a diagnostic tool in patients with OA by comparing with T2 mapping which is widely used in clinical practice. We compared T1rho and T2 mappings for their ability to differentiate between normal and denatured articular cartilage by means of radiological-histological correlation. We concluded that T1rho mapping is superior to T2 mapping for the evaluation of denatured articular cartilage with osteoarthritis of the knee.
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[Presentation] Assessment of T1ρand T2 mapping as biomarkers of denaturalization in articular cartilage with osteoarthritis : comparison with pathological results after total knee replacement2011
Author(s)
Takayama Y, Hatakenaka M, Yoshiura T, Tsushima H, Okazaki K, Nishikawa K, Obara M, Iwamoto Y, Honda H.
Organizer
ISMRM 19th Annual Meeting & Exhibition
Place of Presentation
Montreal, Quebec, Canada
Year and Date
20110507-13