2013 Fiscal Year Final Research Report

A research on the optimal protocol for cryoablation of endocrine organ including adrenal gland and thyroid gland

Research Project

Project/Area Number	23791448
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Keio University
Principal Investigator	SOTA Oguro 慶應義塾大学, 医学部, 助教 (50383716)
Research Collaborator	NAKATSUKA Seishi 慶應義塾大学, 医学部, 講師 (50188984) INOUE Masanori 慶應義塾大学, 医学部, 助教 (30338157) KAWAMURA Masafumi 帝京大学, 医学部, 教授 (70169770)
Project Period (FY)	2011 – 2013
Keywords	凍結療法 / 副腎 / 甲状腺
Research Abstract	Cryoablation of the adrenal gland caused a hypertensive crisis during thawing. This hypertensive crisis was conducted by high plasma catecholamines and was observed rapidly. We concluded that the blood pressure should be monitored and controlled using arterial blood pressure and arterial infusion of alpha-blocker. Cryoablation of the thyroid gland revealed that the area of the ice ball was significantly smaller than that of liver or kidney. The size of the ice ball was different in each experiments. This difference in the size of the ice ball was caused by "heat sink effect" by a regional vessels including common carotid artery or vein.