2012 Fiscal Year Final Research Report
Fundamental investigation about nephrogenic systemic fibrosis (NSF)and gadolinium-based MRI contrast agents
| Project/Area Number |
23791458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 放射性医薬品・造影剤 / 腎性全身性線維症 |
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| Research Abstract |
We have succeeded in quantification and visualization for gadolinium deposition in major organs by applying renal impaired rats were administered each gadolinium-based MRI contrast agent. Also, we can assess the association between nephrogenic systemic fibrosis and each MRI contrast agent including histopathological examination. In additional experiments using hepatorenally impaired rats, and investigated about the risk of nephrogenic systemic fibrosis, including the histopathological examination and gadolinium deposition in major organs for liver-specific MRI contrast agent.
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