Can mTOR become target of the molecular target therapy in esophagus squamous cell carcinoma?

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791551
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: HIRASHIMA Kotaro 熊本大学, 医学部附属病院, 非常勤診療医師 (10594468)
• Research Collaborator: BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905) ; WATANABE Masayuki 熊本大学, 大学院・生命科学研究部, 准教授 (80254639) ; BABA Yoshifumi 熊本大学, 医学部附属病院, 助教 (20599708)
• Project Period (FY): 2011 – 2012
• Keywords: mTOR / RAD001 / 食道扁平上皮癌 / PI3K/Akt / cell cycle / cell growth / apoptosis

Research Abstract

The mammalian target of rapamycin (mTOR) plays central roles inthe regulation of cell growth and proliferation. The aberrant activation of mTOR inrelation to clinical outcome has been reported in several types of cancers. mTOR isincreasingly important as a potential target for anticancer therapy. Nonetheless, aprognostic feature of mTOR activation in esophageal squamous cell carcinoma remainsuncertain.

Research Products

• [Journal Article] Differential expression of basement membrane type IV collagen α2 and α6 chains as a prognostic factor in patients with extrahepatic bile duct carcinoma (2013)
  • Author(s): Hirashima K, Iyama KI, Baba Y, HondaY, Sado Y, Ninomiya Y, Watanabe M,Takamori H, Beppu T, Baba H
  • Journal Title: J Surg Oncol Volume: 107 Pages: 402-407
  • DOI: DOI:10.1002/jso.23225
  • Peer Reviewed
• [Journal Article] Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma (2012)
  • Author(s): Hirashima K, Baba Y, Watanabe M,Karashima RI, Sato N, Imamura Y, NagaiY, Hayashi N, Iyama KI, Baba H
  • Journal Title: Br J Cancer Volume: 106 Pages: 876-82
  • DOI: DOI:1038/bjc.2012.36
  • Peer Reviewed
• [Journal Article] Lymphatic vessel invasion detected by the D2-40 monoclonal antibody is an independent prognostic factor in node-negative esophageal squamous cell carcinoma (2012)
  • Author(s): Imamura Y, Watanabe M, Nagai Y, BabaY, Hirashima K, Karashima R, IwatsukiM, Yoshida N, Kinoshita K, KurashigeJ, Iyama K, Baba H
  • Journal Title: J Surg Oncol Volume: 105 Pages: 277-83
  • DOI: DOI:10.1002/jso.22079
  • Peer Reviewed
• [Journal Article] Usefulness of transcription-reverse transcription concerted reaction method for detecting circulating tumor cells in patients with colorectal cancer (2012)
  • Author(s): Sato N, Hayashi N, Imamura Y, TanakaY, Kinoshita K, Kurashige J, Saito S,Karashima R, Hirashima K, Nagai Y,Miyamoto Y, Iwatsuki M, Baba Y,Watanabe M, Baba H
  • Journal Title: Ann Surg Oncol Volume: 19 Pages: 2060-5
  • DOI: DOI:10.1245/s10434-011-1889-7
  • Peer Reviewed
• [Journal Article] 膵頭部結核性リンパ節炎の 1 例 (2012)
  • Author(s): 平島浩太郎、沖野哲也、田上弘文、木村有、小澄敬祐、松川哲也、八木泰志
  • Journal Title: 日臨外会誌 Volume: 73 Pages: 2353-2356
  • Peer Reviewed
• [Journal Article] Induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for patients with node-positive esophageal cancer (2011)
  • Author(s): Watanabe M, Nagai Y, Kinoshita K,Saito S, Kurashige J, Karashima R,Hirashima K, Sato N, Imamura Y,Hiyoshi Y, Baba Y, Iwagami S, MiyamotoY, Iwatsuki M, Hayashi N, Baba H
  • Journal Title: Digestion Volume: 83 Pages: 146-52
  • DOI: DOI:10.1159/000321797
  • Peer Reviewed
• [Presentation] 高齢者胃癌における GlasgowPrognostic Score(GPS)の検討 (2012)
  • Author(s): 平島浩太郎、渡邊雅之、藏重淳二、木下浩一、斉藤 誠哉、井田 智、石本 崇胤、長井 洋平、岩槻 政晃、岩上 志朗、馬場 祥史、宮本 裕士、別府 透、馬場 秀夫
  • Organizer: 第112回日本外科学会定期学術総会
  • Place of Presentation: 千葉県 幕張メッセ国際展示場
  • Year and Date: 2012-04-12
• [Presentation] 食道扁平上皮癌における mTOR 阻害薬(RAD001)の抗腫瘍効果の検討 (2011)
  • Author(s): 平島浩太郎、馬場祥史、渡邊雅之
  • Organizer: 第111回日本外科学会定期学術総会
  • Place of Presentation: 震災のため紙上開催
  • Year and Date: 20110526-28