2012 Fiscal Year Final Research Report
The activation of dendritic cells and regulatory T cells in sentinel lymph node of esophageal cancer
| Project/Area Number |
23791555
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOGURE Michihiko 福島県立医科大学, 医学部, 講師 (90264548)
OSUKA Fumihiko 福島県立医科大学, 医学部, 助教 (80404870)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食道癌 / 制御性T細胞 / 樹状細胞 |
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| Research Abstract |
Image synthesis method of Single Photon Emission Computed Tomography （SPECT）and Multi-detector raw Computed Tomography(MDCT) is useful way to identify anatomic locations of sentinel nodes.Deference of the number of CD83+DCs and Foxp3+Tregs in hot node and cold node were not observed. The decreased prevalence of CD83+DCs and the increased prevalence of Foxp3+ Tregs were observed in metastatic lymph nodes. It is reasonable to assume that high density of Foxp3+ Tregs plays an important role directly or indirectly in inhibition of local activation of DCs. To investigate its efficacy further, careful monitoring of the two arms of the immune response will be needed.
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