2012 Fiscal Year Final Research Report
Development of lung regeneration therapy with alveolar type II pneumocytes and iPS cells
| Project/Area Number |
23791561
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
SAKAIRI Yuichi 千葉大学, 医学部附属病院, 医員 (30551949)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 呼吸器外科学 / 肺再生 / II 型肺胞上皮細胞 |
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| Research Abstract |
We established an isolation method for lung cells from human resected lung; we verified it as alveolar type II pneumocyte by the electron microscopy and fluorescent immunostaining. These cells were induced expressing the characteristics of alveolar type I pneumocyte by the culture. This human cell source was trans-tracheally injected to pneumonectomized rat, and the integration to rat alveolar wall and construction of new alveolar wall were confirmed. We started new project of differentiation induction from iPS cells to alveolar stem cells, based on the analysis of these isolated cells.
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