2012 Fiscal Year Final Research Report
In vivo MR imaging of bone marrow cells in GBM
| Project/Area Number |
23791595
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 膠芽腫 / MRI / 造血幹細胞 / 分子イメージング |
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| Research Abstract |
We have developed MagA, which is an MR reporter gene, overexpressing transgenic mouse, and pursued the possibility of tracking bone marrow derived cells in the course of glioblastoma development by MRI. We were able to confirm that bone marrow cells from MagA transgenic mouse accumulate more iron than wild type mouse and that those cells showed hypo-intense signals under MRI observation.
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[Journal Article] Novel PET imaging index, 18F-fluorodeoxy glucose/11C-methionine uptake decoupling score, reflects glioma cell infiltration2012
Author(s)
Kinoshita M, Arita H, Goto T, Okita Y, Isohashi K, Watabe T, Kagawa N,Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
J Nucl Med
Volume: 53(11)
Pages: 1701-1708
DOI
Peer Reviewed
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[Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012
Author(s)
Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T
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Journal Title
J Neurosurg
Volume: 116(4)
Pages: 835-842
DOI
Peer Reviewed
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[Journal Article] Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron emission tomography2012
Author(s)
Hirayama R, Watabe T, Isohashi K, Kijima N, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
J Neuro-oncol
Volume: 107(2)
Pages: 379-386
DOI
Peer Reviewed
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[Journal Article] Imaging 18^F-fluorodeoxy glucose/11^C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema2012
Author(s)
Kinoshita M, Goto T, Arita H, Okita Y, Ishohashi K, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Saitoh Y, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
J Neuro-oncol
Volume: 106(2)
Pages: 417-425
DOI
Peer Reviewed
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[Journal Article] Slower growth of skull base meningiomas compared with non-skull base meningiomas based on volumetric and biological studies2012
Author(s)
Hashimoto N, Rabo CS, Okita Y, Kinoshita M, Kagawa N, Fujimoto Y, Morii E, Kishima H, Maruno M, Kato A, Yoshimine T
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Journal Title
J Neurosurg
Pages: 574-580
DOI
Peer Reviewed
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[Journal Article] Significance of Tumor Volume Related to Peritumoral Edema in Intracranial Meningioma Treated with Extreme Hypofractionated Stereotactic Radiation Therapy in Three to Five Fractions.2011
Author(s)
Morimoto M, Yoshioka Y, Shiomi H, Isohashi F, Konishi K, Kotsuma T, Fukuda S, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T, Koizumi M
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Journal Title
Jpn J Clin Oncol
Pages: 609-616
DOI
Peer Reviewed
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