• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Stem cell transplantation for ischemic stroke focusing on timing and lesion specificity

Research Project

  • PDF
Project/Area Number 23791611
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionNagasaki University

Principal Investigator

HORIE Nobutaka  長崎大学, 大学病院, 助教 (70380912)

Project Period (FY) 2011 – 2013
Keywords脳梗塞 / 幹細胞 / 移植 / 再生医療
Research Abstract

Human mesenchymal stem cells were widely distributed both in the peri-infarct and core in D1, and dominantly in the peri-infarct in D4. Very few cells were observed on D7. At day 7 poststroke, microglia activation was significantly suppressed in both the peri-infarct and core in D1, and predominantly in the peri-infarct in D4. At day 21 poststroke, brain-derived neurotrophic factor was widely distributed throughout the peri-infarct in D1 and D4, along with many reactive astrocytes and considerable angiogenesis. Motor function improved earlier in D1 and later in D4, but no recovery was obtained in D7.
Our results indicate that intra-arterial cell transplantation provides timing-dependent cell distribution and poststroke functional recovery via a combination of neuroprotection, reactive astrocyte enhancement, and angiogenesis.

  • Research Products

    (9 results)

All 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Intra-Arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke2013

    • Author(s)
      Shunsuke Ishizaka, Nobutaka Horie【Corresponding Author】, Katsuya Satoh, Yuhtaka Fukuda, Noriyuki Nishida, Izumi Nagata
    • Journal Title

      Stroke

      Volume: 44 Pages: 720-726

    • DOI

      10.1161/STROKEAHA.112.677328

    • Peer Reviewed
  • [Journal Article] Assessment of carotid plaque stability based on the dynamic enhancement pattern in plaque components with multidetector CT angiography2012

    • Author(s)
      Horie N, Morikawa M, Ishizaka S, Takeshita T, So G, Hayashi K, Suyama K, Nagata I.
    • Journal Title

      Stroke

      Volume: 43(2) Pages: 393-8

    • DOI

      10.1161/STROKEAHA.111.635953

    • Peer Reviewed
  • [Journal Article] Direct arteriovenous fistula at the inferolateral trunk mimicking carotid cavernous fistula without involving the cavernous sinus : a case report2012

    • Author(s)
      Horie N, Morikawa M, So G, Hayashi K, Suyama K, Nagata I.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 154(3) Pages: 465-9

    • DOI

      10.1007/s00701-011-1226-8

    • Peer Reviewed
  • [Journal Article] New variant of persistent primitive olfactory artery associated with a ruptured aneurysm2012

    • Author(s)
      Horie N, Morikawa M, Fukuda S, Hayashi K, Suyama K, Nagata I.
    • Journal Title

      J Neurosurg

      Volume: 117(1) Pages: 26-8

    • DOI

      10.3171/2012.3.JNS111932

    • Peer Reviewed
  • [Journal Article] Selective coil embolization through flow-directed microcatheter for intracranial arteriovenous malformations2012

    • Author(s)
      Horie N, Hayashi K, Morikawa M, Nagata I.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 154(6) Pages: 989-91

    • DOI

      10.1007/s00701-012-1287-3

    • Peer Reviewed
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた細胞移植療法の現状と課題2013

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田泉、ラファエル・グズマン、トニア・ブリス、ゲイリー・スタインバーグ
    • Organizer
      Stroke 2013
    • Place of Presentation
      東京
    • Year and Date
      20130321-23
  • [Presentation] Strokeに対するヒト神経幹細胞移植後の内在性修復機構活性化2013

    • Author(s)
      堀江信貴、日宇健、永田泉、Tonya Bliss、Gary K. Steinberg
    • Organizer
      Stroke 2013
    • Place of Presentation
      東京
    • Year and Date
      20130321-23
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた幹細胞移植の可能性2012

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田泉、Raphael Guzman, Tonya Bliss, Gary K Steinberg
    • Organizer
      【シンポジウム"脳血管内治療のリサーチワーク"】第28回日本脳神経血管内治療学会総会
    • Place of Presentation
      仙台
    • Year and Date
      20121115-17
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた幹細胞移植の可能性―経静脈的投与との相違―Endovascular stem cell transplantation for Stroke- difference between IV and IA-2012

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田泉、Raphael Guzman, Tonya Bliss, Gary K Steinberg
    • Organizer
      【シンポジウム"幹細胞と再生医療"】第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      20121017-19

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi