2013 Fiscal Year Final Research Report
Tissue regeneration and fluorescent imaging evaluation of adipose-derived stem cells for bone and soft tissue defect after tumor excision
Project/Area Number |
23791630
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Nagoya City University (2012-2013) Kanazawa University (2011) |
Principal Investigator |
HAYASHI Katsuhiro 名古屋市立大学, 医学(系)研究科(研究院), 講師 (80507054)
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Project Period (FY) |
2011 – 2013
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Keywords | 骨・軟部腫瘍学 |
Research Abstract |
Adipose-derived stem cells (ADSCs) were investigated for regeneration of bone and soft tissue defect after tumor excision. Bone defect model in rat histologically proved better osteogenesis in ADSCs grafted model than in control model. MDM2 was focused for the differences of stem cell differentiation potential. Liposarcoma which has higher amplification of MDM2 showed higher differentiation potential to mesenchymal cells than regular adipose cells.
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[Journal Article] A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgery2014
Author(s)
Fang X, Murakami H, Demura S, Hayashi K, Matsubara H, Kato S, Yoshioka K, Inoue K, Ota T, Shinmura K, Tsuchiya H
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Journal Title
PLoS One
Volume: 19;9(2)
Pages: e88874
DOI
Peer Reviewed
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[Journal Article] Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy2013
Author(s)
Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM
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Journal Title
J Cell Biochem
Volume: 114(11)
Pages: 2454-60
DOI
Peer Reviewed
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[Journal Article] Diagnosis and treatment of low-grade osteosarcoma : experience with nine cases2013
Author(s)
Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Nishida H, Takeuchi A, Kimura H, Miwa S, Inatani H, Okamoto H, Yamada S, Ikeda H, Sawada-Kitamura S, Nojima T, Ooi A, Otsuka T
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Journal Title
Int J Clin Oncol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] TNF-αand tumor lysate promote the maturation of dendritic cells for immunotherapy for advanced malignant bone and soft tissue tumors2012
Author(s)
Miwa S, Nishida H, Tanzawa Y, Takata M, Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Kimura H, Igarashi K, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
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Journal Title
PLoS One
Volume: 7(12)
Pages: e52926
DOI
Peer Reviewed
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[Journal Article] Comparison of Cancer-Cell Seeding, Viability and Deformation in the Lung, Muscle and Liver, Visualized by Subcellular Real-time Imaging in the Live Mouse2011
Author(s)
Hayashi K, Kimura H, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Hasegawa A, Bouvet M, Hoffman RM
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Journal Title
Anticancer Res
Volume: 31
Pages: 3665-72
Peer Reviewed
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[Journal Article] Activity of bone morphogenetic protein-7 after treatment at various temperatures : Freezing vs. pasteurization vs. allograft2011
Author(s)
Takata M, Sugimoto N, Yamamoto N, Shirai T, Hayashi K, Nishida H, Tanzawa Y, Kimura H, Miwa S, Takeuchi A, Tsuchiya H
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Journal Title
Cryobiology
Volume: 63
Pages: 235-239
DOI
Peer Reviewed
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[Presentation] Long-term histological findings of oncologically sterilized autoclaved bone, irradiated bone and frozen bone2013
Author(s)
Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Nishida H, Takeuchi A, Tanazawa Y, Inatani H, Okamoto H, Yamada S, Otsuka T
Organizer
低温医学学会総会
Place of Presentation
今池ガスビル(名古屋)
Year and Date
20131128-29
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[Presentation] Multicenter Study of Caffeine-potentiated Chemotherapy for Bone and Soft Tissue Sarcoma2012
Author(s)
Hayashi K, Tsuchiya H, Takeuchi A, Otsuka T, Hoshi M, Ieguchi M, Chosa E, Sakamoto T, Tajino T, Yamada H, Yokouchi M, Sakayama K, Kidani T, Isobe K, Maehara H, Tome Y
Organizer
9th Asia Pacific Musculoskeletal Tumor Society Meeting (APMSTS)
Place of Presentation
Hilton Kuala Lumpur (Malaysia)
Year and Date
20120907-09
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[Presentation] Comparison of Sarcoma Cell Seeding, Viability and Deformation in the Lung, Muscle and Liver, Visualized by Subcellular Real-Time Imaging in the Live Mouse2011
Author(s)
Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Nishida H, Tanzawa Y, Takeuchi A, Kimura H, Miwa S, Igarashi K, Hoffman RM
Organizer
International Society of Limb Salvage/Musculoskeletal Tumor Society Combined Meeting
Place of Presentation
China National Convention Center (China)
Year and Date
2011-09-17