2012 Fiscal Year Final Research Report
Neural and vascular specific microRNA as a novel approach for the treatment of injured spinal cord
| Project/Area Number |
23791646
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 再生医療 / 再生医学 / 神経科学 |
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| Research Abstract |
Administration of microRNA-210 to the spinal cord injury models enhanced angiogenesis, astrogliosis, axon growth and functional recovery following injury. Administration of microRNA-210 downregulated the expression of PTP1B, P-Erk1/2, EFNA3 and promoted Wnt signaling. These might participate in the mechanisms of spinal cord regeneration through the promotion of angiogenesis.
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