2012 Fiscal Year Final Research Report
Research on descending pain control mechanism
| Project/Area Number |
23791693
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 下行性抑制系 / ノルアドレナリン / 青斑核 |
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| Research Abstract |
To address the cellular mechanisms underlying pain modulation we have developed a patch-clamp recording technique from LC neurones in anaesthetized rats. These recordings showed LC discharge in vivo to be driven by both spontaneous membrane potentialoscillations. This approach allows detailed characterisation of the synaptic and integrative mechanisms of LC responses to naturalistic stimulation.
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