2012 Fiscal Year Final Research Report
The secretions from neuroendocrine cell promotes gelsolin-mediated motility of prostate cancer
| Project/Area Number |
23791765
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 前立腺癌 / 神経内分泌細胞 / 去勢抵抗性 / ゲルゾリン、進展 |
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| Research Abstract |
The purpose of this study was to investigate the interactions between NE cells and LNCaP cells and the involvement of gelsolin in contributing to invasive potential of LNCaP cells. The present study indicates that neuroendocrine (NE) cells and neurotensin induced gelsolin-mediated motility of LNCaP cells through NTSR1 activation involving phospholipase C- intracellular calcium ion mobilization.
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