2012 Fiscal Year Final Research Report
Identification of novel urine biomarkers using molecules which was Specifically expressed in bladder cancer
| Project/Area Number |
23791782
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TAKATA Ryo 岩手医科大学, 医学部, 講師 (00438467)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 膀胱癌 / バイオマーカー / 遺伝子 |
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| Research Abstract |
As new diagnostic tools of bladder cancer, we attempted to establish novel urine biomarker for the bladder cancer. Although we analyzed gene expression levels of MPHOSPH1 and DEPDC1, contamination of white blood cells affected the results. Therefore we corrected contamination level using expression levels of CD13 and CD31. As a results, when we use CD31 expression as correction factor, Expression levels of MPHOSPH1 and DEPDC1 of bladder cancer patients were higher than that of normal controls. Protein expression level showed similar result.
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