2012 Fiscal Year Final Research Report
The analysis of physiological function of FOXL2 in human ovary.
| Project/Area Number |
23791815
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OISHI Hajime 東京大学, 医学部附属病院, 助教 (40401088)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生殖医学 / FOXL2 / 卵胞発育 / ステロイド合成 |
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| Research Abstract |
The physiological role of FOXL2 in human granulosa and luteal cellsFOXL2, a forkhead transcription factor gene, have recently been demonstrated to be causative to granulosa cell tumor or primary ovarian failure. FOXL2 is expressed mostly in periocular and ovarian granulosa cells but its function and role remain unknown. Herein we investigated the physiological role of FOXL2 in folliculogenesis and steroidogenesis by ovarian granulosa cells. We clarified the target genes of FOXL2 that are related to sex steroidogenesis and folliculogenesis and FOXL2 is shown to play as a transcription factor in target gene promoters. Thus, FOXL2 is shown to be crucial in the regulationof ovarian function.
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[Journal Article] Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression2012
Author(s)
Shirane A, Wada-Hiraike O, Tanikawa M, Seiki T, Hiraike H, Miyamoto Y, Sone K, Hirano M, Oishi H, Oda K, Kawana K, Nakagawa S, Osuga Y, Fujii T, Yano T, Kozuma S, Taketani Y
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Journal Title
Biochem Biophys Res Commun
Volume: 424(3)
Pages: 604-10
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[Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary2012
Author(s)
Morita Y, Wada-Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, Koyama S, Oishi H, Yoshino O, Miyamoto Y, Sone K, Oda K, Nakagawa S, Tsutsui K,Taketani Y
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Journal Title
Reprod Biol Endocrinol
Volume: 23
Pages: 10-14
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[Presentation] 抗老化分子SIRT1活性化物質レスベラトロールは細胞接着分子E-cadherinの発現を制御し胚の子宮内膜接着能を向上させる2012
Author(s)
白根晃,平池修,谷川道洋,平野茉来,森田吉洋,櫻橋彩子,傳厚掬,大石元,織田克利,川名敬,藤井知行,矢野哲,上妻志郎
Organizer
第17回日本生殖内分泌学会学術集会
Place of Presentation
東京
Year and Date
20121200
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