2013 Fiscal Year Final Research Report
Potential defense mechanisms against oxidative stress and inflammation for the placenta in modulating adverse environment to the fetus
| Project/Area Number |
23791833
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KONDOH Eiji 京都大学, 医学(系)研究科(研究院), 講師 (10544950)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 妊娠高血圧腎症 / 酸化LDL / 酸化LDL受容体LOX-1 / 脂質代謝 / 酸化ストレス / Nrf2 |
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| Research Abstract |
Serum concentration of oxidized low-density lipoprotein (oxLDL) is higher in women with preeclampsia than in normal pregnant woman. Lectin-like oxLDL receptor-1 (LOX-1) is one of the scavenger receptors for oxLDL and is abundantly expressed in placenta. It is well known that oxLDL activates nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and cytoprotective genes such as heme oxygenase-1 (HO-1), which play an important role in preeclampsia.
Both LOX-1 expression and Nrf2 activation were significantly decreased in preeclamptic placentas compared with normal controls. A significant decrease in LOX-1 mRNA was found in placental explant cultures under hypoxic conditions. Activation of Nrf2 up-regulated HO-1 in both the JAR cells and placental explants. Furthermore, oxLDL increased HO-1 mRNA, whereas the blockade of LOX-1 inhibited the increase of HO-1 mRNA in JAR cells.
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