Establishment of endothelial cells from placental vessels derived iPS cells and Generation of therapeutic strategies for disease model animals.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23791863
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo (2012-2014); National Research Institute for Child Health and Development (2011)
• Principal Investigator: MAKINO HATSUNE 東京大学, 分子細胞生物学研究所, 研究員 (90392498)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 心疾患 / 細胞治療 / 胎盤 / 心筋細胞 / 心筋前駆細胞 / 心筋分化誘導 / 心組織再生

Outline of Final Research Achievements

Cell lines derived from human placenta and amnion have been established. And also it has been shown that these cells differentiate into cardiomyocytes and vascular cells. In this study, using the above cell, the possibility of new treatments for various types of heart disease such as heart failure and myocardial infarction were examined. Several iPS cell lines derived from human placenta and amniotic-derived cells were established. Factor responsible for homeostasis of cardiovascular not only endothelial cell-specific molecule was listed up as genes that characterize placental vascular endothelial cells. Cells that can differentiate into cardiomyocytes were localized in the part of tissue derived from fetus of mouse placenta. Myocardial progenitor cell-specific gene-positive cells were observed in the labyrinth layer and chorion frondosum of mouse placenta. These results are novel findings indicate that cells with myocardial differentiation ability were localized in placenta.

Free Research Field

細胞生物学