2013 Fiscal Year Final Research Report
Evaluation of the diagnostic value of 3T-MRI intratympanic injection of GBCA for Menieres disease
| Project/Area Number |
23791889
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 耳科学 / メニエール病 / MRI / 画像診断 |
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| Research Abstract |
To investigate the relationship between 3T MRI after intratympanic injection of GBCA, the glycerol test, and ECoG in patients with Menieres disease (MD). A total of 20 patients with MD were evaluated. Diluted gadodiamide (a gadolinium-based contrast agent) was administered to the bilateral tympanic cavity by injection through the tympanic membrane. After 24 h, the endolymphatic hydrops was evaluated by a 3.0 T MR scanner. To investigate cochlear hydrops, the glycerol test and ECoG were carried out in all patients. As a esults a positive result was observed in 11 patients (55%) in the glycerol test and in 12 patients (60%) by ECoG. The incidence of positive findings when evaluating the same patients with both the glycerol test and ECoG increased to 75%. Nineteen of 20 (95%) patients showed positive results for 3T MRI.
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