2013 Fiscal Year Final Research Report
the pathophysiology of the inflammation in the eosinophilic otitis media
| Project/Area Number |
23791900
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | サイトカイン / 好酸球 / 中耳炎 |
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| Research Abstract |
The middle ear effusion was collected from the patients with eosinophilic otitis media. The inflammatory factors in middle ear effusion were examined by cytokine array. Multiple inflammatory factors were observed in middle ear effusion in patients with eosinophilic otitis media. The animal study was carried out in BALB/c mice by immunization with ovalbumin mixed with aluminum hydroxide. The mice showed a accumulation of eosinophils in middle ear mucosa, and had many inflammatory factors in middle ear cavity. The mice showed similar pathophysiology as humans with eosinophilic otitis media.
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[Journal Article] Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D(2) receptor (DP)-dependent pathway2011
Author(s)
Motoharu Eguchi, Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Seiichiro Makihara, Tazuko Fujiwara, Kinya Nagata, Hiroyuki Hirai, Shuh Narumiya, Masataka Nakamura, Kazunori Nishizaki
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Journal Title
Clin Exp Immunol
Volume: vol.163
Pages: 250-269
DOI
Peer Reviewed
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