2012 Fiscal Year Final Research Report
Mucosal immune response associated with NKT cell activation innasopharyx for the development of prospective mucosal vaccine
| Project/Area Number |
23791909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Oita University |
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Principal Investigator |
NODA Kenji 大分大学, 医学部耳鼻咽喉科, 助教 (90511171)
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| Project Period (FY) |
2011 – 2012
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| Keywords | NKT細胞 / a-ガラトクトシルセラミド / 経鼻免疫 / 中耳炎予防ワクチン / P6 |
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| Research Abstract |
Specific IgA plays an important role in the elimination of pathogen.In this study, we demonstrated that CD4+T cells expressing P6-specific Th1 and Th2cytokine mRNA, which is important for the induction of the specific S-IgA immune response,were induced after intranasal immunization with P6 and α－GalCer. These findings suggestthat nasal vaccination with P6 and α-GalCer might be an effective regimen for mucosalvaccine.
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