2012 Fiscal Year Final Research Report
The investigation for pathogenesis of glaucoma and the overcome of complications of filtering surgery via focusing on transthyretin
| Project/Area Number |
23791993
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 家族性アミロイドポリニューロパチー / 緑内障 / トランスサイレチン / トラベクレクトミー |
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| Research Abstract |
Secondary glaucoma is the most serious ocular manifestation of transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP). We investigated the mechanism of bleb encapsulation, which is a complication of filtering surgery. TTR-aggregated amyloid did not cause any change for fibroblast in vitro in physiolosical condition. Subconjunctival TTR-aggregated amyloid embedded in Poly-HEMA in rat might cause mild inflammation.
Also, TTR concentration in aqueous humor is significantly higher and TTR is significantly oxidized in glaucomatous eyes.
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Research Products
(3 results)
