Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23792089
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Tokai University
• Principal Investigator: YAMAGIWA Takeshi 東海大学, 医学部, 講師 (70439727)
• Project Period (FY): 2011 – 2012
• Keywords: シアン化合物 / 解毒剤 / イミダゾール・シクロデキストリン

Research Abstract

The purpose of this study was to evaluate an imidazole cyclodextrin (FeIIIPIm3CD) which we have developed as an antidote for acute cyanide poisoning. Both in vitro study using murine fibroblast cell and in vivo study using mice, FeIIIPIm3CD demonstrated a significantantidotal effect against potassium cyanide, which was more effective than that of existing antidote (cobalt compounds).

Research Products

• [Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning (2013)
  • Author(s): Yamagiwa T, Kawaguchi AT, Saito T, Inoue S, Morita S, Watanabe K, Kitagishi H, Kano K, Inokuchi S.
  • Journal Title: Human and Experimental Toxicology
  • Peer Reviewed
• [Presentation] 青酸に対するイミダゾール配位超分子鉄ポルフィリン(ImCD)の解毒効果;マウスin vivoにおける検討 (2012)
  • Author(s): 山際武志
  • Organizer: 第40回日本救急医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-15
• [Presentation] Imidazole cyclodextrin as a novel antidote for acute cyanide poisoning: Comparison with existing antidotes (2012)
  • Author(s): Yamagiwa T
  • Organizer: 16th International Society of Burn Injury (ISBI 2012).
  • Place of Presentation: Edinburgh(Scotland)
  • Year and Date: 2012-09-10
• [Presentation] 急性シアン化合物中毒に対する新たな全合成解毒剤"イミダゾール・シクロデキストリン"のin vitroにおける効果 (2011)
  • Author(s): 山際武志
  • Organizer: 第39回日本救急医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-19
• [Presentation] Imidazole cyclodextrin; totallysynthetic supramolecular complex as an antidote for cyanide poisoning (2011)
  • Author(s): Yamagiwa T
  • Organizer: 38th Congress of European Society of Artificial Organs
  • Place of Presentation: Porto (Portugal)
  • Year and Date: 2011-10-10
• [Presentation] Imidazole cyclodextrin as an antidote against cyanide poisoning, in vitro and in vivo study (2011)
  • Author(s): Yamagiwa T
  • Organizer: The International Association of Forensic Toxicology (TIAFT 2011).
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2011-09-30
• [Presentation] In vitroにおけるシアン化合物に対する解毒剤の評価方法の確立 (2011)
  • Author(s): 山際武志
  • Organizer: 第33回日本中毒学会総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-07-31