2012 Fiscal Year Final Research Report
VEGF as a Potential Candidate for Developing Novel Therapy and Diagnosis for MODS in Sepsis: Development of microcirculation-based therapeutic and diagnostic approach in sepsis
| Project/Area Number |
23792095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba (2012)
Research Institute, International Medical Center of Japan (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 敗血症 / 多臓器障害 / VEGF / 微小循環異常 |
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| Research Abstract |
We prospectively studied
(1) the relationships between angiogenic factors, their soluble receptors and organ dysfunction and
(2) the effects of disseminated intravascular coagulation (DIC)-induced platelet consumption, thrombin generation, and tissue hypoxia on the expression of the factors and receptors
Fifty patients with sepsis were classified into two subgroups: 37 patients with DIC and 13 patients without DIC. We found, VEGF, sVEGFR1, Ang2, and Ang1/Ang2, especially Ang2, may have roles in the development of MODS in sepsis associated with DIC, and VEGF, sVEGFR1, and Ang2 serum levels correlated with the extent of DIC-induced platelet consumption, thrombin generation, and blood lactate levels.
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[Journal Article] Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: Comparison with acute coagulopathy of trauma-shock2013
Author(s)
Yanagida Y, Gando S, Sawamura A, Hayakawa M, Uegaki S, Kubota N, Homma T, Ono Y, Honma Y, Wada T, Jesmin S
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