Protein secretion system in Periodonto-pathic Bacteria

2012 Fiscal Year Final Research Report

• Project/Area Number: 23792109
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: SATO Keiko 長崎大学, 医歯薬学総合研究科, 助教 (70410579)
• Project Period (FY): 2011 – 2012
• Keywords: 歯周病 / 病原因子

Research Abstract

The gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity. Particulary, cysteine proteases, named gingipains, are important virulence factors because of degradation of host proteins and responsibility for processing/maturation of P. gingivalis virulence factors. The PorSS is involved in the secretion of the proteins containing CTD that are essential for colony pigmentation, hemeagglutination, adherence, and virulence of bacterial pathogen of P. gingivalis.

Research Products

• [Journal Article] Identification of Porphyromonas gingivalis proteins secreted by the Por secretion system. (2013)
  • Author(s): Sato K, Yukitake H, Narita Y, Shoji M, Naito M, Nakayama K.
  • Journal Title: FEMS Microbiol Lett Volume: 338(1) Pages: 68-76
  • DOI: DOI: 10.1111/1574-6968.
  • Peer Reviewed
• [Presentation] (2013)
  • Author(s): Sato K, Nakane D, Yukitake H, McBride,Nakayama K
  • Organizer: 第85回細菌学会
  • Place of Presentation: 千葉
  • Year and Date: 20130300
• [Presentation] シンポジウム招待講演 (2012)
  • Author(s): Sato K, Nakane D, Wada H, Imada K, M. McBride, Nakayama K
  • Organizer: 第50回生物物理学会
  • Place of Presentation: 名古屋
  • Year and Date: 20120900