2012 Fiscal Year Final Research Report

Research in the interaction of dopaminergic functions in the basal ganglia

Research Project

Project/Area Number	23792133
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Functional basic dentistry
Research Institution	Hoshi University
Principal Investigator	IKEDA Hiroko 星薬科大学, 薬学部, 講師 (70297844)
Project Period (FY)	2011 – 2012
Keywords	歯科薬理学
Research Abstract	Central dopamine (DA) systems are key players in the cerebral organization of behavior and various diseases. We show that stimulation of DA D_1/2 receptors in the accumbal shell decreased dorsal striatal DA efflux via a direct or indirect feed-forward loop involving shell, core, ventrolateral striatum (VLS) and dorsal striatum (DS): stimulation of D_1/2 receptors in the shell decreased DA efflux in the core; inhibition ofD_1/2 receptors in the core increased DA efflux in the VLS, and stimulation of D_1/2 receptors in the VLS decreased DA efflux in the DS. Finally, stimulation of D_1/2 receptors in the shell decreased DA efflux in the DS. Thus, we provide evidence in favor of the existence ofspiraling striato-nigro-striatal connections.

(4 results)