2012 Fiscal Year Final Research Report
Novel therapeutic strategy for oral squamous cell carcinoma by targeting angiogenesis signal.
| Project/Area Number |
23792154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 癌 / 遺伝子 / 間質誘導 |
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| Research Abstract |
We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on VEGF family expression in oral cancer cell line, HSC-3. Moreover, we investigated the effect of several inhibitors for AP-1, AKT and mTOR on VEGF family expression under SB stimulation.There are minimal difference in VEGF-A mRNA expression level between control and SB treated groups, however, we identified decrease of VEGF-B VEGF-C and VEGF-D mRNA expression. Moreover, angiogenic factor, angiopoientin-2 and platelet derived growth factor beta mRNA were decreased by SB treatment. These data suggest that SB inhibits stromal inducement in invasive oral carcinoma.
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