2015 Fiscal Year Final Research Report
Analysis of outbreak mechanism of the pain on dentin-pulp complex.
| Project/Area Number |
23792178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
Tatsuyama Shoko 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (70347095)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Keywords | TRPM8 / 象牙芽細胞 / 温度感受性受容体 |
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| Outline of Final Research Achievements |
In this study, we confirmed the expression of the transient receptor potential melastatin-8 (TRPM8) in human dental pulp cells and in mouse odontoblasts. Using rat dental pulp slice culture as a dentin-pulp complex models we further revealed TRPM8 expression in rat odontoblasts. Our results indicated that odontoblasts could directly respond to noxious stimuli, example as cold condition, and transduce the signal to the nearby nerves, accordingly odontblasts may be involved in dentin hypersensitivity.
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| Free Research Field |
医歯薬学
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