2012 Fiscal Year Final Research Report
Development and Evaluation of Drug Cocktails Containing BioinorganicElements and BMP-2 by Genetic Algorithms
| Project/Area Number |
23792272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka Dental University (2012)
Tohoku University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 情報工学 / BMP-2 / 骨再生 / 幹細胞 |
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| Research Abstract |
I established a novel expeditious drug screening approach, Feedback system control (FSC) with differential evolution, to search for optimal drug cocktails that induced osteoblastogenesis of mesenchymal stem cells. With an adequate biomarker, FSC process robustly elicited prospective drug cocktails containing bone morphogenic protein 2 (BMP-2), which concentration was lower than one hundredth of conventional osteogenic media.
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