2012 Fiscal Year Final Research Report
The study on RIG-I function analysis for establishment of innovativetherapy for mucositis induced by chemotherapy
| Project/Area Number |
23792308
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
KUBOTA Kosei 弘前大学, 医学部附属病院, 助教 (10529689)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯学 / 遺伝子 / 口腔粘膜炎 |
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| Research Abstract |
The purpose of this study was to establish new therapy of oral mucositis induced by chemotherapy. Cultured human gingival fibroblasts were stimulated with docetaxel, LPS and polyIC, and examined the expression of RIG-I and inflammatory cytokines mRNA. The cDNA microarray indicated the expression of type I interferon. RIG-I may have some roles in pathogenesis of oral mucositis induced by chemotherapy in gingivalfibroblasts.
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