2012 Fiscal Year Final Research Report
Development for the cancer therapy to regulate cell cycle and stimulating immune system by novel gene networks
| Project/Area Number |
23792309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子 / 癌 / 歯学 / RIG-I |
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| Research Abstract |
n the present study, we aimed to perform functional analysis of RIG-I using an oral carcinoma-derived cell line in order to clarify the signal transduction pathway of RIG-I, with the aim of regulating the cell cycle in oral cancer cells and stimulating immune system. In addition to RIG-I, DAI (DLM-1/ZBP1) and MDA-5 were analyzed with molecular biological method. Our data indicate RIG-I may have important roles in activation of caspase in apoptosis.
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