Inferior alveolar nerve regeneration after missing bone segments

2014 Fiscal Year Final Research Report

• Project/Area Number: 23792332
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: ISOMURA Emiko 大阪大学, 医学部附属病院, 助教 (70397701)
• Research Collaborator: SHOGEN Yosuke 大阪大学歯学部附属病院, 口腔外科(制御系), 医員
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経再生 / 仮骨延長

Outline of Final Research Achievements

Bifocal distraction osteogenesis has been shown to be a reliable method for reconstructing missing bone segments. However, there are no reports regarding inferior alveolar nerve regeneration duringthat. We assumed that the nerve could regenerate with the bone regeneraton duringbifocal distraction, if the nerve was saved at a mesial site of the transport disc. In the present study, we investigated the possibility of that in dogs.
Using a bifocal distraction osteogenesis method, we produced a 10-mm mandibular defect including the nerve defect and distracted the transport disc at a rate of 1 mm/day in 12 dogs. The regenerated nerve was evaluated histologically and electrophysiologically. Our results indicate that inferior alveolar nerve regeneration after t bifocal distraction osteogenesis was successful in dogs. Although our research is still at the stage of animal experiments, future application in humans is considered to be possible.

Free Research Field

口腔外科