2013 Fiscal Year Final Research Report
Investigation of oral mucosal inflammatory disease developing mechanism via Toll-like receptor
| Project/Area Number |
23792346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
NISHI Hiromi 広島大学, 大学病院, 助教 (70403558)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 口腔粘膜炎症性疾患 / 口腔粘膜上皮細胞 / 歯肉線維芽細胞 / Toll-like receptor |
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| Research Abstract |
Oral keratinocytes and fibroblasts may augment host defense and inflammatory responses against oral microorganisms invasion. However, it remains unclear whether oral keratinocytes and fibroblasts produce specific inflammatory proteins in response to Pathogen-associated molecular patterns (PAMPS) and associated with oral mucosal inflammatory diseases. Our results showed that oral keratinocytes and fibroblasts expressed mRNA of TLRs 1-10. IL-8 and CXCL10 production from oral keratinocytes and fibroblasts was induced by treatment with various TLR agonisits. These findings suggest that recognition of microorganism-derived pathogen in oral keratinocytes and fibroblasts by TLR may have important role to orchestrate host immune responses and promoting hyper/hypo reactions related to oral inflammatory diseases via production of various chemokines.
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