The mechanism of cleft palate after palatal fusion -Effect of MEOX2-

2013 Fiscal Year Final Research Report

• Project/Area Number: 23792394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: IMURA HIDETO 愛知学院大学, 歯学部, 非常勤講師 (10513187)
• Project Period (FY): 2011 – 2013
• Keywords: 口蓋裂 / 発生 / MEOX2 / 離開

Research Abstract

Cleft palate must therefore be induced by a disruption during the developmental process of the palatal shelves. We reported that some embryos appeared to develop cleft palates after palatal fusion by TCDD.On the other hand, the same present status has been reported in mesenchyme homeobox 2(Meox2) knockout mouse. We observed MEOX2 gene from the blood of the patient of a human cleft palate.Sequence analysis was conducted to 99 Japanese cleft palate patients.
Candia et al. reported that the MEOX2 gene is expressed in a wide range of mesodermal structures, including the developing limbs, groups of muscles of the head, and the developing palate. Mankoo et al. reported that MEOX2 was essential for normal muscle formation and for the normal regulation of myogenic genes, as demonstrated by the downregulation of Pax3.A possibility that the variation of MEOX2 had affected by vulnerability of palatal muscle after palatal fusion was suggested.

Research Products

• [Journal Article] 声門下気道狭窄を認めた口唇顎裂患者の1例 (2014)
  • Author(s): 井村英人, 新美照幸, 藤原久美子, 南克浩, 古川博雄, 加藤大貴, 森明弘, 大野磨弥, 原田純, 夏目長門
  • Journal Title: 日本口蓋裂学会雑誌 Volume: 39(1) Pages: 41-45
• [Journal Article] Beckwith-Wiedemann症候群の臨床的研究―インプリント遺伝子解析と臨床経過を中心として― (2014)
  • Author(s): 加藤大貴, 井村英人, 東元健, 八木ひとみ, 芝崎龍典, 古川博雄, 新美照幸, 藤原久美子, 鈴木聡, 外山佳孝, 南克浩, 井上知佐子, 早川統子, 副島英伸, 夏目長門
  • Journal Title: 日本口蓋裂学会雑誌 Volume: 39(1) Pages: 21-27
• [Journal Article] Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P) (2013)
  • Author(s): Butali A, Suzuki S, Cooper ME, Mansilla AM, Cuenco K, Leslie EJ, Suzuki Y, Niimi T, Yamamoto M, Ayanga G, Erkhembaatar T, Furukawa H, Fujiwawa K, Imura H, Petrin AL, Natsume N, Beaty TH, Marazita ML, Murray JC
  • Journal Title: Am J Med Genet A Volume: 161A(5) Pages: 965-972
• [Presentation] 口蓋形成後の口蓋裂発生メカニズム―MEOX2に着目してー (2014)
  • Author(s): 井村英人, 鈴木聡, 大野磨弥, 森明弘, 山田朋弘, 森悦秀, 菅原利夫, 夏目長門
  • Organizer: 日本口蓋裂学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20140529-30
• [Presentation] The mechanism of cleft palate after palatal fusion Hideto Imura (2013)
  • Author(s): H Imura, S Suzuki, M Ono, K Minami, K Fujiwara, T Kato, N Natsume
  • Organizer: CLEFT2013 ICPF
  • Place of Presentation: HANOI, Vietnam
  • Year and Date: 20131125-28
• [Presentation] A case of Tetrasomy 15q with left cleft lip and alveolus (2013)
  • Author(s): H IMURA, S SUZUKI, K MINAMI, T KATO, T Hayakawa, N NATSUME
  • Organizer: 12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomaies Hilton Orlando Lake Buena Vista
  • Place of Presentation: Florida USA
  • Year and Date: 20130505-10
• [Presentation] 声門下気道狭窄を認めた口唇顎裂患者の1例 (2013)
  • Author(s): 井村英人, 新美照幸, 藤原久美子, 南克浩, 加藤大貴, 大野磨弥, 森明弘, 夏目長門
  • Organizer: 日本口蓋裂学会
  • Year and Date: 20130400
• [Presentation] 口唇口蓋裂を認めたoral-facial-digital syndromeの一例 (2013)
  • Author(s): 井村英人, 鈴木聡, 新美照幸, 藤原久美子, 南克浩, 古川博雄, 加藤大貴, 大野磨弥, 森明弘, 森智子, 菅原利夫, 夏目長門
  • Organizer: 日本口蓋裂学会
  • Year and Date: 20130400
• [Presentation] 左側口唇顎裂を伴ったTetrasomy 15qの一例 (2011)
  • Author(s): 井村英人・古川博雄・鈴木聡・新美照幸・南克浩・藤原久美子・加藤大貴・大野磨弥・夏目長門
  • Organizer: 日本口腔外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-21