2012 Fiscal Year Final Research Report
Molecular mechanism of the differentiation control by the mechanical stimulation of the mesenchymal cells which is in the process of chondrocyte differentiation
Project/Area Number |
23792414
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Tohoku University |
Principal Investigator |
KUMIKO Kosaka 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (30585336)
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Project Period (FY) |
2011 – 2012
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Keywords | 機械的刺激 / 軟骨細胞分化 / MAPK |
Research Abstract |
In this study, I found that mechanical compressive stimulation promoted chondrogenic differentiation of mesenchymal cells derived from rat lim bud but stretch stimulation inhibited it. In addition, phosphorylation and nuclear translocation of ERK-1/2 were observed after mechanical stretch stimulation. Therefore, activation of ERK-1/2 pathway by mechanical stimulation is involved in mechano-sensing signaling pathway of chondrogenesis.
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