|Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
In this study, I found that mechanical compressive stimulation promoted chondrogenic differentiation of mesenchymal cells derived from rat lim bud but stretch stimulation inhibited it. In addition, phosphorylation and nuclear translocation of ERK-1/2 were observed after mechanical stretch stimulation. Therefore, activation of ERK-1/2 pathway by mechanical stimulation is involved in mechano-sensing signaling pathway of chondrogenesis.