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2012 Fiscal Year Final Research Report

Analysis of osteoclastogenesis regulated by orthodontic force

Research Project

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Project/Area Number 23792455
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

ARAI Atsushi  松本歯科大学, 歯学部, 助教 (00532772)

Project Period (FY) 2011 – 2012
Keywords破骨細胞 / 破骨細胞前駆細胞 / RANK / RANKL / c-Fos / M-CSF / c-fmsマクロファージ / 矯正力 / 歯の移動
Research Abstract

We previously reported that osteoclast precursors were detected as RANK-positive cells in bone tissues. RANK-positive cells were observed in bone tissues in RANKL-/- mice, but not in c-Fos-/- mice. c-Fos, but not RANKL, is required for the up-regulation of RANK in osteoclast precursors. Then, we analyzed the mechanism of c-Fos-mediated up-regulation of RANK in osteoclast precursors. Our results suggest that c-Fos plays essential roles not only in RANKL-induced formation of osteoclasts but also in M-CSF-induced formation of osteoclast precursors.

  • Research Products

    (9 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL 34 expression in osteopetrotic op/op mice.2012

    • Author(s)
      Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Sato M, Penniger JM, Yasuda Y, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N
    • Journal Title

      PNAS. Jun

      Volume: 19(109) Pages: 10006-10011

    • DOI

      doi:10.1073/pnas.1207361109

    • Peer Reviewed
  • [Journal Article] Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment.2012

    • Author(s)
      Arai A, Mizoguchi T, Harada S, Kobayashi Y, Nakamichi Y, Yasuda H, Penninger JM, Yamada K, Udagawa N, Takahashi N
    • Journal Title

      J Cell Sci. Feb;

      Volume: 12(125) Pages: 2910-17

    • DOI

      doi:10.1242/jcs.099986

    • Peer Reviewed
  • [Journal Article] Lineage-committed osteoclast precursors circulate in blood and settle down into bone.2011

    • Author(s)
      Muto A, Mizoguchi T, Udagawa N, Ito S, Kawahara I, Abiko Y, Arai A, Harada S, Kobayashi Y, Nakamichi Y, Penninger JM, Noguchi T, Takahashi N
    • Journal Title

      J Bone MinerRes.Dec;

      Volume: 26(12) Pages: 2978-90

    • DOI

      doi:10.1002/jbmr.490

    • Peer Reviewed
  • [Presentation] 2012 the American Society for Bone and Mineral Research Annual Meeting 2012 年 10月 c-Fos plays an essential role in up-regulation of RANK expression in osteoclast precursors A. Arai2012

    • Author(s)
      T. Mizoguchi , Y. Kobayashi ,T. Yamashita,K. Yamada , J. M. Penninger , N. Udagawa,N. Takahashi
    • Organizer
      Journal of Bone and Mineral Research 23, suppl 1: S179,
    • Year and Date
      20120000
  • [Presentation] in vivoにおける破骨細胞分化機構の解析-M-CSFはc-Fosを介し前駆細胞のRANKを上昇する2011

    • Author(s)
      荒井敦, 溝口利英, 小林泰浩, 山 下照仁, 山田一尋, 宇田川信之, 高橋直之
    • Organizer
      松本歯科大学学会
    • Year and Date
      20110700
  • [Presentation] 生体内における破骨細胞分化機構の解析-M-CSF は c-Fos を介して破骨細胞前駆細胞の RANK 発現を上昇する-2011

    • Author(s)
      荒井 敦 , 溝口利英, 原田卓, 武藤昭紀, 小林泰浩, 山 下照仁, 保田尚孝, 山田一尋,宇田川信 之, 高橋直之
    • Organizer
      第29回日本骨代謝学会
    • Year and Date
      20110700
  • [Presentation] 月c-Fos 遺伝子欠損マウスを用いた BMP 誘導 性異所性骨形成に関する解析中村みどり2011

    • Author(s)
      二宮 禎,溝口利英,荒 井敦 , 高橋直之, 宇田川信之
    • Organizer
      第29回日本骨代謝学会
    • Year and Date
      20110700
  • [Presentation] IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting ANZBMS Annual Scientific Meeting, with JSBMR2011年 9月BMP-induced ectopic bone formation in c-Fos-deficient mice2011

    • Author(s)
      M. Nakamura, T. Ninomiya, T. Mizoguchi, A. Arai, N. Takahashi, N. Udagawa
    • Organizer
      第2回アジア太平洋骨粗鬆症学会プログラム抄録集
    • Year and Date
      20110000
  • [Presentation] IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting ANZBMS Annual Scientific Meeting, with JSBMR2011 年 9 月 c-Fos plays an essential role in up-regulation of RANK expression in osteoclast precursors2011

    • Author(s)
      A. Arai, T. Mizoguchi , Y. Kobayashi ,T.Yamashita, K. Yamada , J. M. Penninger , N. Udagawa, N. Takahashi
    • Organizer
      第2回アジア太平洋骨粗 鬆症学会プログラム抄録集
    • Year and Date
      20110000

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Published: 2014-09-25   Modified: 2015-11-26  

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