2012 Fiscal Year Final Research Report
Identification of signaling mechanism of bone resorption and redox control in the aging mouse model
| Project/Area Number |
23792526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
OMATA Kazuhiko 日本歯科大学, 生命歯学部, 非常勤講師 (00434142)
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| Project Period (FY) |
2011 – 2012
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| Keywords | redox / 骨代謝 / 加齢 |
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| Research Abstract |
In this study, we analyzed the molecular mechanism of bone metabolism due to aging changes, using the aging mouse-derived cells. We found that increased expression of redox-related molecules txnip decrease differentiation of osteoclast activity in vitro. The reduction of bone metabolic function due to aging, txnipmay regulate osteoclast genesis.
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