2012 Fiscal Year Final Research Report
The analysis of inflammatory responses and effective care in chronic wounds
| Project/Area Number |
23792534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fundamental nursing
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| Research Institution | Tohoku University |
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Principal Investigator |
KANNO Emi 東北大学, 大学院・医学系研究科, 助教 (10431595)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 看護技術 / 創傷治癒 / 感染 / 炎症 / 免疫 |
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| Research Abstract |
Several bacteria, including Pseudomonas aeruginosa exist in chronic wounds with prolonged inflammatory reaction. In the present study, using a rat model with full-thickness dermal wounds, we examined the effect of P. aeruginosa and quorum sensing (QS) molecules, N-(3-oxododecanoyl)-_L-homoserine lactone (3-oxo-C_<12>-HSL), which is produced by P. aeruginosa. Within 3 days, inoculation with P. aeruginosa or3-oxo-C_<12>-HSL had accelerated local infiltration of neutrophils and tumor necrosis factor-α. These results indicate that 3-oxo-C_<12>-HSL may be involved in induction of inflammatory responses.
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[Journal Article] Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted byN-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa2013
Author(s)
Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Hirono Otomaru, Arina Hatanaka, Shiori Sato, Keiko Ishii, Denso Hayashi, Nobuhito Shibuya, Yoshimichi Imai, Naomasa Gotoh, Ryoko Maruyama and Masahiro Tachi
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Journal Title
Journal of Dermatological Science
Volume: 70
Pages: 130-138
URL
Peer Reviewed
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