2012 Fiscal Year Final Research Report
Analysis for endocannabinoid signaling in the epileptogenic circuit
| Project/Area Number |
23800001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 内因性カンナビノイド / カンナビノイド受容体 CB1 / 歯状回 / てんかん |
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| Research Abstract |
This research project reveled the molecular anatomical basis fora major endocannabinoid, 2-arachidonoyl glycerol (2-AG), to effectively inhibit synaptic transmission at mossy cell-granule cell synapses, which constitute a potentiaepilectogenic circuit in the CNS. This suggests that 2-AG plays a role as a synapticcircuit breaker to prevent the epiletogenesis.
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Research Products
(18 results)
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[Journal Article] Localization of acetylcholine-related molecules in theretina: implication of thecommunication from photoreceptor toretinal pigment epithelium2012
Author(s)
Matsumoto H, Shibasaki K, Uchigashima M,Koizumi A, Kurachi M, Moriwaki Y,Misawa H, Kawashima K, Watanabe M,Kishi S, Ishizaki Y
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Journal Title
PLoS One
Volume: 7(8)
Pages: e42841
DOI
Peer Reviewed
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[Journal Article] Unbalance of CB1 receptors expressed inGABAergic and glutamatergic neurons ina transgenic mouse model ofHuntington's disease2012
Author(s)
Chiodi V, Uchigashima M, Beggiato S,Ferrante A, Armida M, Martire A,Potenza RL, Ferraro L, Tanganelli S,Watanabe M, Domenici MR, Popoli P
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Journal Title
Neurobiol Dis
Volume: 45(3)
Pages: 983-91
DOI
Peer Reviewed
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