2012 Fiscal Year Final Research Report
Identification of microRNA expression profile of cancer stem cells
| Project/Area Number |
23800039
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 癌幹細胞 / マイクロRNA / エクソゾーム / 情報ネットワーク |
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| Research Abstract |
In this study, we have identified specific microRNAs that regulate angiogenesis and histone modification in liver cancer stem cell (CSC) fraction. In colorectal cancer, we have also identified microRNA profiles of CSC fraction. These microRNAs were mainly involved in the secretary type and suggested to effect on surrounding microenvironmentfor cancer progression and metastasis.
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[Journal Article] Depletion of JARID1B induces cellular senescence in human colorectal cancer2013
Author(s)
Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamot
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Journal Title
Int J Oncol
Volume: 42(4)
Pages: 1212-8
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[Journal Article] CD49f-positive cell population efficiently enriches colon cancer cancer-initiating cells
Author(s)
Haraguchi N, Ishii H, Mimori K, OhtaK, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Yamamoto H, Doki Y, Mori M
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Journal Title
Int J Oncol
Volume: (Accepted)
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