2012 Fiscal Year Final Research Report
Development of cancer Immunotherapy targeting BTLA
| Project/Area Number |
23800043
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor immunology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAMADA Koji 山口大学, 大学院・医学系研究科, 教授 (00615841)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 免疫チェックポイント機構 / 免疫共シグナル分子 / 腫瘍反応性 T リンパ球 |
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| Research Abstract |
This project aims at optimized regulation of immune co-signal functions so as to induce potent anti-tumor immunotherapy. For this purpose, we have generated a fusion protein consisting extracellular domain of BTLA and immunoglobulin Fc region, which could deliver stimulatory co-signal while attenuating inhibitory co-signal simultaneously. Whereas this protein induced T cell activation, its injection led to no apparent anti-tumor effect in animal models. We plan to re-construct this protein in order to increase its immune activity and re-examine anti-tumor effects in vivo.
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Research Products
(8 results)
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[Journal Article] Expression of anti-HVEM single chain antibody on tumor cells induces tumor-specific immunity with long-term memory.2012
Author(s)
Park, J.J., Anand, S., Zhao, Y., Matsumura, Y., Sakoda, Y., Kuramasu, A., Strome, S.E., Chen, L. and Tamada K.
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Journal Title
Cancer Immunol. Immunother
Volume: 61
Pages: 203-214
DOI
Peer Reviewed
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