2012 Fiscal Year Final Research Report
Analysis of physiological roles of HACD1 and pathogenesis of myopathies.
| Project/Area Number |
23890001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHNO Yusuke 北海道大学, 大学院・薬学研究院, 助教 (50611498)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 極長鎖脂肪酸 / 3-ヒロキシアシルCoA脱水酵素 / ミオパチー |
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| Research Abstract |
HACD1 is a protein engaged in elongation of very long-chain fatty acids, and is specifically expressed in heart and skeletal muscle. In this study, we demonstrated that HACD1 is involved in elongation of saturated fatty acids, whose carbon chain lengths are 16 to 26. We created Hacd1 knockout mice, and decreases in weight, muscle mass, and locomotor activity were observed in Hacd1 knockout mice.
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[Presentation] and Fanny Pilot-Storck Of Dogs, Mice, and Cells: Role of HACD1 in Muscle Development and Physiology2013
Author(s)
Jordan Blondelle, Yusuke Ohno, Marie Maurer, Gemma Walmsley, Sebastien Storck, Laurent Guillaud1, Jean Demarquoy, Richard Piercy, Akio Kihara, Laurent Tiret
Organizer
53rd International conference on the Bioscience of Lipids
Place of Presentation
Banff, Canada.Banff Centre.
Year and Date
20130905-08
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