2012 Fiscal Year Final Research Report
Functional analysis of viral RNA recognition sensor MDA5
| Project/Area Number |
23890004
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Keywords | 自然免疫 / MDA5 |
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| Research Abstract |
Previous reports shown that RIG-I-like receptor, includes RIG-I, MDA5 senses the presence of virus specific double-strand RNA (dsRNA), thereby activating innate immune system in the cells invaded by virus.Here our study identified that SCI2 bind with Polyinosinic:polycytidylic acid (poly I:C), subsequent serve as positive regulatory molecule in the downstream innate immunity-related inflammatory pathways.Our data, moreover, not only show SCI2 plays a potent role for stimulating IFN activation during viral infection, but bind with MDA5, sensor of poly I:C, suggesting that SCI2 participate in the regulation of MDA5-mediated antiviral innate immunity.
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