2012 Fiscal Year Final Research Report
Genome-wide association study for abnormal cranio-facial morphology
| Project/Area Number |
23890011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Fumio 北海道大学, 北海道大学病院, 医員 (00612889)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯学 |
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| Research Abstract |
Two loci (1q32.2 and 1p22.3) were likely to be as novel susceptibility regions of mandibular prognathism.PLXNA2 and SSX2IP genes were considered as a genetic candidate.PLXNA2 gene is a gene encoding semaphorin co-receptors, and the relations to bone metabolism are reported in semaphorin 3A.SSX2IP gene is related to a Synovium Sarcoma and the temporomandibular joint that is related to mandibular growth has synovial tissue. We speculate that these genes may be also associated with mandibular prognathism.
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