2012 Fiscal Year Final Research Report
Alteration of snRNAs in amyotrophic lateral sclerosis
| Project/Area Number |
23890060
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ALS / snRNA / U12 snRNA / スプライシング / 逆転写定量PCR |
|---|
| Research Abstract |
We stated and investigated the hypothesis that the dysfunction of TDP-43 causesreduction of snRNAs in amyotrophic lateral sclerosis (ALS). We revealed thedownregulation of U12 snRNA in the tissues affected with ALS and not in non-affectedtissues. Several U12-type intron splicing tended to be downregulated in ALS affectedtissues and culture cells with depleted TDP-43.
|
Research Products
(4 results)
