2012 Fiscal Year Final Research Report
Regulation of the ERK-MAPK cascade and cell-transformation by MEKsumoylation
| Project/Area Number |
23890077
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo (2012)
Nagoya University (2011) |
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Principal Investigator |
KUBOTA Yuji 東京大学, 医科学研究所, 助教 (70614973)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 癌 / ERK / SUMO / MAPK |
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| Research Abstract |
We found MEK sumoylation strongly attenuated its kinase activity and inhibited the ERK pathway by disrupting the specific docking interaction between MEK and ERK. Interestingly, the Ras oncogene inhibited MEK sumoylation, and forced enhancement of MEK sumoylation suppressed Ras-induced cell transformation. These data indicates that the ablation of MEKsumoylation by the specific oncogene contributes to carcinogenesis.
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