2011 Fiscal Year Final Research Report
Analysis of tissue macrophage development and its function in vivo
| Project/Area Number |
23890095
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
ISE Masako (KOHYAMA Masako) 大阪大学, 微生物病研究所, 特任研究員(常勤) (70311339)
|
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| Project Period (FY) |
2011
|
| Keywords | リンパ球 / 自然免疫 / 免疫監視 |
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| Research Abstract |
Red pulp macrophage(RPM) is a tissue macrophage which localized in spleen. Spi-C is a transcriptional factor that control RPM development. We made Spi-C IRES-GFP knock-in mouse and Spi-C conditional knockout mice. We identified cells that had a potential to differentiate into RPMs. And also, we found the factor, one of the metabolite of red blood cell, which could induce Spi-C expression
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