2012 Fiscal Year Final Research Report
Analysis of the host factor which is important for ovarian cancer dissemination
| Project/Area Number |
23890100
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
HASHIMOTO Kae 大阪大学, 医学系研究科, 助教 (90612078)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 卵巣癌 / 腹膜播種 / SDF-1 |
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| Research Abstract |
This study was focused on the effect of SDF-1 on the ovarian cancer peritoneal dissemination. Stromal cell derived factor-1 (SDF-1) increased in the ascites of ovarian cancer model mice. SDF-1 promoted adhesion and invasion of ovarian cancer cell lines in vitro. Immunostaining showed SDF-1 was secreted from vascular pericytes or fibroblasts and tumor of TOV21G cell line. SDF-1 neutralizing antibody delayed tumor growth of advanced ovarian cancer model mice and prolonged survival.
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Research Products
(5 results)
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[Journal Article] Low-dose metronomic oral dosing of a prodrug of Gemcitabine (LY2334737) causes anti-tumor effects in the absence of inhibition of systemic vasculogenesis.2012
Author(s)
Francia G, Shaked Y, Hashimoto K, Sun J, Yin M, Cesta C, Xu P, Man S, Hackl C, Stewart J, Uhlik M, Dantzig A. H, Foster S, Kerbel R. S.
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Journal Title
Mol Cancer Ther
Volume: 11
Pages: 680-689
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