2012 Fiscal Year Final Research Report
Involvement of epigenetic regulation in the expressions of decidualization related genes
| Project/Area Number |
23890140
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
TAMURA Isao 山口大学, 医学部附属病院, 助教 (40610663)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 子宮内膜間質細胞 / 脱落膜化 / ヒストンアセチル化 |
|---|
| Research Abstract |
The promoter regions of IGFBP-1 and PRL showed hypomethylated DNA status and high histone acetylation status in human endometrial stromal cell (ESC), suggesting the loose chromatin structure of the promoter regions, which allows transcription factors to bind the response element of the promoter when decidualization-related transcriptional factors are recruited.
|
